1a. Repeat the Entrez tutorial with your assigned protein and use Uniprot to get to know the protein.
1b. In addition review the literature on your protein.
Each of you have a member of the ARAP family of proteins and you will be focusing on one of the PH domains of this protein for your term project.
GHA – NP_001035207.1
2. Write a draft introduction which includes the following elements:
What is the ARAP protein family? What are the function(s) of these proteins? Why are they important? Any diseases associated with mutations or malfunction of these proteins?
What is known about the particular member you have been assigned? What pertinent questions have not been addressed so far about this protein? Any unique features compared to the rest of the family?
What do we know about the role of PH domain in the overall function of this family of proteins? Which other kind of proteins house this domain? What is the structure-function relationship of this domain fold? Any characteristics or hallmarks? Is there is a canonical function?
What is known and not known about your assigned sequence specifically its PH domain and its function ? What do you hope to find? What could be possible goals of your study using bioinformatics? Can you frame a hypothesis regarding the function of the PH domain of your sequence?
Note: Writing style – strictly scientific.
This is going to be the introduction for the term paper. A sample one will be attached it’s about myosin and this will be about ARAP family protein in general for the first question and then specific about my protein assigned NP_001035207.1
For Info about protein type the number (NP_001035207.1) on NCBI and uniPort.
The writing style should be scientific